Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
| Autor: | Yanan Lu, Timothy C. Germann, Adrian Enriquez, Ruben Diaz Avalos, Marit J. van Gils, Ana G. Lujan Hernandez, Yoann Aldon, Guojun Lang, Mohammad M. Sajadi, Elizabeth Feeney, John Ingraham, Georgia D. Tomaras, Milite Abraha, Junli Liu, Jacob Glanville, S. Moses Dennison, Minsoo Kim, Erica Ollmann Saphire, Sawsan Youssef, Ross S. Federman, Gillian Q. Horn, Bingqing Shen, Sean Hui, Anne L. Palser, Joseph M. Fernandez, Gevorg Grigoryan, Vamseedhar Rayaprolu, David D. Ho, Jieyun Yin, Sharon L. Schendel, Jian Yu, Haoyang Li, Shelly J. Krebs, Qian Zhang, Ronald R. Cobb, Colin Mann, Eduardo Olmedillas, Rogier W. Sanders, Robin Green, Hyeong Mi Kim, Tierra Buck, Dawid Zyla, Hanif Ali, Paul Kellam, Terence H. Rabbitts, Diptiben V. Parekh, Anna J. MacCamy, Cheolmin Kim, Kuan-Ying A. Huang, Milan T. Tomic, Andrew T. McGuire, Tom Z. Yuan, Chitra Hariharan, Zahra Rikhtegaran Tehrani, Bjoern Peters, Xiaoying Yu, Sooyoung Lee, CoVIC-DB team, Kan Li, Leonidas Stamatatos, Cheuk Lun Leung, Chao Kong, Michelle Zandonatti, Fei Lan, Yongcong Tan, Aaron K. Sato, Kathryn M. Hastie, Liang Schweizer, Sanja Aracic, Jonne L. Snitselaar, Weidong Jiang, Kelly Shaffer, Jimin Seo, Daniel Bedinger |
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| Přispěvatelé: | Medical Microbiology and Infection Prevention, AII - Infectious diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Multidisciplinary Coronavirus disease 2019 (COVID-19) biology Immunodominant Epitopes SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Protein domain COVID-19 Antibodies Viral Virology Antibodies Neutralizing Epitope Article Epitope mapping Protein Domains Spike Glycoprotein Coronavirus biology.protein Humans Antibody Antigens Viral Epitope Mapping Protein Binding |
| Zdroj: | Science, 374(6566), 478-472. American Association for the Advancement of Science Science |
| ISSN: | 0036-8075 |
| Popis: | Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover or spillback events between humans and animals. To develop prevention and therapeutic strategies, we formed an international consortium to map the epitope landscape on the SARS-CoV-2 spike protein, defining and structurally illustrating seven receptor binding domain (RBD)–directed antibody communities with distinct footprints and competition profiles. Pseudovirion-based neutralization assays reveal spike mutations, individually and clustered together in variants, that affect antibody function among the communities. Key classes of RBD-targeted antibodies maintain neutralization activity against these emerging SARS-CoV-2 variants. These results provide a framework for selecting antibody treatment cocktails and understanding how viral variants might affect antibody therapeutic efficacy. |
| Databáze: | OpenAIRE |
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