Handheld multi-modal imaging for point-of-care skin diagnosis based on akinetic integrated optics optical coherence tomography
| Autor: | Wolfgang Drexler, Eduardo Margallo-Balbás, Jose Luis Rubio-Guviernau, Juan Lloret-Soler, Juan Sancho-Durá, Kirill Zinoviev |
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| Rok vydání: | 2018 |
| Předmět: |
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Materials science Point-of-Care Systems General Physics and Astronomy 02 engineering and technology 01 natural sciences General Biochemistry Genetics and Molecular Biology 010309 optics 020210 optoelectronics & photonics Optics Planar Optical coherence tomography 0103 physical sciences Microscopy 0202 electrical engineering electronic engineering information engineering Medical imaging Miniaturization medicine Humans General Materials Science Skin Microelectromechanical systems medicine.diagnostic_test business.industry General Engineering Equipment Design General Chemistry Hand business Sensitivity (electronics) Tomography Optical Coherence |
| Zdroj: | Journal of Biophotonics. 11:e201800193 |
| ISSN: | 1864-063X |
| DOI: | 10.1002/jbio.201800193 |
| Popis: | A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co-registered in a common-path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 × 19.5 mm2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low-voltage Micro Electro-Mechanical System (MEMS) mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 × 27 × 14 mm3 , achieves an isotropic resolution of ~11 μm in tissue, -93 dB sensitivity, 12 mm lateral field of view, and an axial scanning range of 2.8 mm in air. The complete battery-powered device has a weight of 3 kg in a tablet format, enabling point-of-care use cases. This work shows that integration of complementary imaging modalities through miniaturization technology results in clinically valuable instruments supporting a patient-centered diagnostic imaging workflow. |
| Databáze: | OpenAIRE |
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