Effects of hypoxia on the circadian patterns in men
| Autor: | Jacopo P. Mortola, Fabio Faralli, P G Data, Gerardo Bosco, Saverio Panico, Alessandro Ionadi, Riccardo Gagliardi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Blood Pressure Biology Body Temperature Oxygen Consumption Heart Rate Reference Values Internal medicine Heart rate medicine Humans Circadian rhythm Hypoxia Public Health Environmental and Occupational Health General Medicine Thermoregulation Effects of high altitude on humans Hypoxia (medical) Middle Aged Circadian Rhythm Endocrinology Blood pressure Control of respiration Respiratory Mechanics Wakefulness medicine.symptom |
| Popis: | We tested the hypothesis that acute hypoxia may alter the circadian pattern of body temperature in adult humans. Six healthy subjects were studied in normoxia, hypoxia (approximately 13% inspired O(2)), and again normoxia, each session lasting24 h and spaced a few days apart, with a constant routine protocol of sustained wakefulness and minimal activity. Some parameters (e.g., tympanic and abdominal temperatures, heart rate) were recorded continuously; others (e.g., oxygen consumption and pulmonary ventilation) were monitored for approximately 10 min every 2 h. The amplitudes of the circadian oscillation of tympanic, abdominal, and calf skin temperatures were reduced in hypoxia, averaging, respectively, 61%, 80% and 50% of the normoxic amplitude. Oxygen consumption and pulmonary ventilation, which presented a circadian pattern in normoxia, had no longer significant oscillations during hypoxia, whereas the opposite was the case for heart rate and diastolic pressure. Therefore, acute hypoxia can disturb the normal circadian patterns and, specifically, depress those of body temperature. These effects, qualitatively similar to those observed in chronically hypoxic animals and humans, could contribute to sleep disturbances at high altitude. |
| Databáze: | OpenAIRE |
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