Clinical Presentation and Outcome of Bladder Schistosoma–Unrelated Squamous Cell Carcinoma: Report on 33 Consecutive Cases
| Autor: | Mohamed Chebil, Nadia Kourda, Ben Slama Mohamed Riadh, Mohamed Sfaxi, Amine Derouiche, Rabii El Atat |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Urology medicine.medical_treatment Urinary system Disease Cystectomy Metastasis Pathogenesis Schistosomiasis haematobia Internal medicine medicine Animals Humans Child Survival rate Aged Neoplasm Staging Retrospective Studies Aged 80 and over Urinary Bladder Calculi Chemotherapy business.industry Middle Aged medicine.disease Urinary Bladder Neoplasms Urinary Tract Infections Carcinoma Squamous Cell Schistosoma haematobium Female business Bladder stone |
| Zdroj: | Clinical Genitourinary Cancer. 5:409-412 |
| ISSN: | 1558-7673 |
| DOI: | 10.3816/cgc.2007.n.027 |
| Popis: | Background Pure squamous cell carcinoma (SCC) is a rare entity in Western countries. The management of SCC still remains similar to that of transitional carcinoma, although it is a different entity. A retrospective review is helpful in understanding the epidemiologic aspects, pathogenesis, and treatment and prognosis of schistosomaunrelated SCC. Patients and Methods Between 1987 and 2002, 30 men and 3 women had been treated for pure SCC of the bladder, not related to bilharzias. Results The mean age of patients was 59 years (range, 29-83 years). They constitute 1.2% of all bladder tumors. At presentation, 2 patients had a distant metastasis. Eleven patients (34%) had a bladder stone with recurrent urinary tract infection; they had been treated since age 6-17 years. Twenty-one patients underwent radical cystectomy, followed by chemotherapy in 2 cases. At a mean follow-up of 5 years, 14 patients (66.6%) died of locoregional disease, with associated metastasis in 5 cases. Seven patients (33.3%) are alive without any evidence of disease. The survival rate was correlated with tumor stage. Conclusion The unrelated SCC has an unfavorable prognosis, mostly caused by the locally advanced disease at the time of presentation. Distant metastases are not rare. The transfer of novel chemotherapy regimens and preoperative radiation therapy should be considered because pelvic recurrences are the leading cause of progression in SCC. |
| Databáze: | OpenAIRE |
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