Ectopic ACTH Secretion Secondary to Metastatic Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of Current Evidence for Systemic Therapy
| Autor: | Emma De Winton, Louise Wade, Paul Kitching |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Epidemiology medicine.medical_treatment Case Report Disease Acinic cell carcinoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adrenocorticotropic Hormone Internal medicine lcsh:Pathology medicine acinic cell carcinoma Neoplasm Humans Disseminated disease ectopic adrenocorticotrophic hormone 030223 otorhinolaryngology Safety Risk Reliability and Quality Cushing Syndrome lcsh:R5-920 Chemotherapy business.industry Carcinoma Acinar Cell salivary gland tumor Middle Aged medicine.disease Carboplatin Parotid gland ACTH Parotid Neoplasms ACTH Syndrome Ectopic medicine.anatomical_structure chemistry Paclitaxel 030220 oncology & carcinogenesis lcsh:Medicine (General) business Safety Research lcsh:RB1-214 |
| Zdroj: | Journal of Investigative Medicine High Impact Case Reports Journal of Investigative Medicine High Impact Case Reports, Vol 8 (2020) |
| ISSN: | 2324-7096 |
| Popis: | Acinic cell carcinoma is a rare, typically indolent, neoplasm that arises in the salivary glands. Metastatic disease is uncommon, occurring in around 10% of cases. We report the case of a 46-year-old male in whom the first sign of disseminated disease was increased skin pigmentation due to paraneoplastic Cushing’s syndrome. He underwent 3 cycles of chemotherapy with carboplatin and paclitaxel with no symptomatic improvement and a mixed response on imaging. There is no evidence that systemic therapy prolongs survival in metastatic acinic cell carcinoma, and we lack a consensus as to which treatment options are most beneficial. A summary of published evidence regarding choice of palliative chemotherapy regimens and response is discussed in relation to the case. |
| Databáze: | OpenAIRE |
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