Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish Health 2000 survey
| Autor: | Antti Jula, Olavi Ukkola, Elina Malo, Mika Kähönen, Markku S. Nieminen, Maarit Jokela, Veikko Salomaa, Y. Antero Kesäniemi, Leena Moilanen |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Logistic regression Cohort Studies Diagnostic Techniques Endocrine Insulin resistance Risk Factors Internal medicine Internal Medicine medicine Prevalence Health Status Indicators Humans Resistin education Finland Aged Metabolic Syndrome education.field_of_study business.industry nutritional and metabolic diseases Middle Aged medicine.disease Obesity Health Surveys Endocrinology Cross-Sectional Studies Cohort Female Metabolic syndrome business Dyslipidemia |
| Zdroj: | Metabolic syndrome and related disorders. 9(3) |
| ISSN: | 1557-8518 |
| Popis: | Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the association of resistin with metabolic syndrome and its components in a population-based cohort.A subsample of a large Finnish cross-sectional health examination survey (the Health 2000 Survey) was studied. Resistin was measured using an in-house assay based on the DELFIA® technique in 1,508 Finnish men and women aged 45-74 years. Metabolic syndrome was defined according to five different definitions.Resistin levels were higher in the subjects with metabolic syndrome when compared to the subjects without metabolic syndrome (P 0.05 for every metabolic syndrome criterion). In logistic regression analysis, a high resistin level was an independent predictor of the prevalence of metabolic syndrome (P 0.05 for every criterion). Resistin was positively associated with waist circumference, tumor necrosis factor-α, and insulin resistance assessed by the homeostasis model and inversely with total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after adjusting for age, gender, and body mass index (P 0.05 for all).These results clarify the controversial association of resistin in obesity and metabolic syndrome, suggesting that a high resistin level is associated with clustering of metabolic disturbances. |
| Databáze: | OpenAIRE |
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