Evaluation of activated charcoal and lipid emulsion treatment in model of acute rivaroxaban toxicity
| Autor: | Zamir Kemal Ertürk, Saffet Özdemir, Egemen Akincioglu, Sezen Bağlan Uzunget, Togay Evrin, Sinan Cem Uzunget, Atila Korkmaz |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_mechanism_of_action Factor Xa Inhibitor Administration Oral 030204 cardiovascular system & hematology Gastroenterology Drug Administration Schedule Mice 03 medical and health sciences 0302 clinical medicine Rivaroxaban Internal medicine medicine Animals Blood Coagulation Blood coagulation test Prothrombin time Mice Inbred BALB C medicine.diagnostic_test business.industry Significant difference 030208 emergency & critical care medicine General Medicine Lipids Activated charcoal Charcoal Toxicity Prothrombin Time Emergency Medicine Lipid emulsion Blood Coagulation Tests Drug Overdose business Injections Intraperitoneal Factor Xa Inhibitors medicine.drug |
| Zdroj: | The American Journal of Emergency Medicine. 36:1346-1349 |
| ISSN: | 0735-6757 |
| DOI: | 10.1016/j.ajem.2017.12.039 |
| Popis: | Aim Reducing or reversing the toxicity effects of new oral anticoagulants is an important question.The purpose of the present study is to evaluate the effect of lipid emulsion (LE) and Activated Charcoal (AC) therapy on the intoxication of rivaroxaban, on mice. Methods Adult male Balb/c mice weighing approximately 30 g were used in the study. Seven groups were assigned, with six mice in each group. Groups were defined; given only rivaroxaban, given only LE, given only AC, after the administration of rivaroxaban LE applied group in the 1st hour, after the administration of rivaroxaban LE applied group in the 3rd hour, after the administration of rivaroxaban AC applied group in the1st hour, after the administration of rivaroxaban AC applied group in the 1st hour and LE applied group in the 3rd hour. PT and Anti-Factor Xa activity were measured in all blood samples from subjects. Results A statistically significant difference was found when all groups were compared in terms of mean PT values and Anti-FactorXa values. However, no statistically significant difference was found in the mean PT and Anti-FactorXa values when only rivaroxaban administrated group and after the administration of rivaroxaban LE and/or AC applied groups were compared one to one. No deaths occurred in groups during the observation. Conclusion Although the administration of either AC or LE alone or in combination resulted in a decrease in the mean values of PT and anti-Factor Xa, in case of rivaroxaban toxicity, but one-to-one comparison of the groups was not statistically significant. |
| Databáze: | OpenAIRE |
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