Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part I: Dioxygenated 4-Methyl Coumarins as Superb Antioxidant and Radical Scavenging Agents
| Autor: | H G, Raj, V S, Parmar, S C, Jain, S, Goel, Poonam, Himanshu, S, Malhotra, A, Singh, C E, Olsen, J, Wengel |
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| Rok vydání: | 1998 |
| Předmět: |
Antioxidant
Chemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Pharmaceutical Science Free Radical Scavengers In Vitro Techniques Biochemistry Antioxidants Rats Lipid peroxidation Structure-Activity Relationship chemistry.chemical_compound Coumarins Drug Discovery Microsomes Liver medicine Animals Vitamin E Molecular Medicine Organic chemistry Lipid Peroxidation Molecular Biology Scavenging |
| Zdroj: | Bioorganic & Medicinal Chemistry. 6:833-839 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/s0968-0896(98)00043-1 |
| Popis: | Twenty-three 4-methylcoumarins bearing different functionalities have been examined for the first time for their effect on NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish structure–activity relationship. Dihydroxy- and diacetoxy-4-methylcoumarins produced dramatic inhibition of lipid peroxidation. 7,8-Diacetoxy-4-methylcoumarin and 7,8-dihydroxy-4-methylcoumarin were found to possess superb antioxidant and radical scavenging activities. |
| Databáze: | OpenAIRE |
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