Botulinum toxin, physical and occupational therapy, and neuromuscular electrical stimulation to treat spastic upper limb of children with cerebral palsy: a pilot study

Autor: Leticia Díaz-Martínez, Alberto Isaac Perez-SanPablo, Antonio Miranda-Duarte, Gerardo Rodríguez-Reyes, Aldo Alessi-Montero
Rok vydání: 2010
Předmět:
Male
medicine.medical_specialty
Modified Ashworth scale
Biomedical Engineering
Medicine (miscellaneous)
Bioengineering
Electric Stimulation Therapy
Pilot Projects
Injections
Intramuscular
Severity of Illness Index
Cerebral palsy
law.invention
Biomaterials
Upper Extremity
Disability Evaluation
Physical medicine and rehabilitation
Randomized controlled trial
Occupational Therapy
law
medicine
Spastic
Humans
Spasticity
Botulinum Toxins
Type A
Range of Motion
Articular
Child
Physical Therapy Modalities
business.industry
Cerebral Palsy
General Medicine
Wrist
medicine.disease
Botulinum toxin
Combined Modality Therapy
Biomechanical Phenomena
medicine.anatomical_structure
Treatment Outcome
Neuromuscular Agents
Muscle Spasticity
Child
Preschool
Physical therapy
Upper limb
Feasibility Studies
Female
medicine.symptom
business
Range of motion
medicine.drug
Zdroj: Artificial organs. 34(3)
ISSN: 1525-1594
Popis: Spasticity has been successfully managed with different treatment modalities or combinations. No information is available on the effectiveness or individual contribution of botulinum toxin type A (BTA) combined with physical and occupational therapy and neuromuscular electrical stimulation to treat spastic upper limb. The purpose of this study was to assess the effects of such treatment and to inform sample-size calculations for a randomized controlled trial. BTA was injected into spastic upper limb muscles of 10 children. They received 10 sessions of physical and occupational therapy followed by 10 sessions of neuromuscular electrical stimulation on the wrist extensors (antagonist muscles). Degree of spasticity using the Modified Ashworth scale, active range of motion, and manual function with the Jebsen hand test, were assessed. Meaningful improvement was observed in hand function posttreatment (P = 0.03). Median spasticity showed a reduction trend and median amplitude of wrist range of motion registered an increase; however, neither of these were significant (P > 0.05). There is evidence of a beneficial effect of the combined treatment. Adequate information has been obtained on main outcome-measurement variability for calculating sample size for a subsequent study to quantify the treatment effect precisely.
Databáze: OpenAIRE
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