Increase of vascular endothelial growth factor and interleukin-6 in the aqueous humour of patients with macular oedema and central retinal vein occlusion
| Autor: | Takashi Sone, Seiyo Harino, Hideharu Funatsu, Tatsuya Mimura, Hidetaka Noma, Sadao Hori |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Pars plana medicine.medical_specialty genetic structures medicine.medical_treatment Visual Acuity Ischemia Enzyme-Linked Immunosorbent Assay Vascular permeability Vitrectomy Cataract Extraction Macular Edema Aqueous Humor chemistry.chemical_compound Central retinal vein occlusion Ophthalmology Retinal Vein Occlusion medicine Humans Fluorescein Angiography Aged medicine.diagnostic_test Interleukin-6 business.industry Aqueous humour General Medicine medicine.disease Fluorescein angiography eye diseases Surgery Vascular endothelial growth factor medicine.anatomical_structure chemistry Female sense organs business Tomography Optical Coherence |
| Zdroj: | Acta Ophthalmologica. 88:646-651 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.2009.01524.x |
| Popis: | Acta Ophthalmol. 2010: 88: 646–651 Abstract. Purpose: This study aimed to investigate whether vascular endothelial growth factor (VEGF) or interleukin-6 (IL-6) influence macular oedema in patients with central retinal vein occlusion (CRVO). Methods: Sixteen consecutive patients with unilateral CRVO and macular oedema were studied, along with eight age- and sex-matched patients without ischaemic ocular disease. Retinal ischaemia was evaluated from capillary non-perfusion on fluorescein angiography. Macular oedema was examined by optical coherence tomography. Aqueous humour (AH) samples were obtained during combined pars plana vitrectomy and cataract surgery, and were examined by enzyme-linked immunosorbent assay. Results: Aqueous levels of VEGF and IL-6 were significantly elevated in patients compared with controls (p = 0.0142 and p |
| Databáze: | OpenAIRE |
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