OXPHOS deficiency induces mitochondrial DNA synthesis through non-canonical AMPK-dependent mRNA compartmentalization

Autor:	Milon, Banik, Samit, Adhya
Rok vydání:	2022
Předmět:	Adenosine Triphosphate Humans Animals Oligomycins RNA Messenger General Medicine AMP-Activated Protein Kinases General Agricultural and Biological Sciences DNA Mitochondrial General Biochemistry Genetics and Molecular Biology Rats
Zdroj:	Journal of Biosciences. 47
ISSN:	0973-7138
DOI:	10.1007/s12038-022-00303-5
Popis:	Eukaryotic cells contain multiple copies of mitochondrial DNA (mtDNA) in discrete organelles or as tubular networks throughout the cytoplasm. The mtDNA copy number is dynamically regulated by mitochondrial biogenesis and mitophagy processes. However, the conditions regulating mtDNA replication, an essential component of biogenesis, are unknown. We observed that short-term (2 h) treatment of rat myoblasts with oligomycin, a specific inhibitor of the mitochondrial F1F0 ATP synthase, resulted in stimulation of mtDNA synthesis from the O
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d68674a52010b70899340f44a0bc459 https://doi.org/10.1007/s12038-022-00303-5 Zobrazit plný text záznamu Full text from SpringerLink