The effects of vasopressin, theophylline and cyclic 3'-5'-adenosine monophosphate (cyclic AMP) on sodium transport across the frog skin
| Autor: | Walten I. Baba, Mary M. Townshend, Anthony J. Smith |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Vasopressin Nutrition and Dietetics Physiology Adenine Nucleotides Vasopressins Sodium Skin Absorption chemistry.chemical_element Biological Transport Active Adenosine monophosphate.cyclic Endocrinology chemistry Theophylline Physiology (medical) Internal medicine medicine Animals Sodium Isotopes Efflux Anura Frog Skin medicine.drug |
| Zdroj: | Quarterly journal of experimental physiology and cognate medical sciences. 52(4) |
| ISSN: | 0033-5541 |
| Popis: | The effects of vasopressin, theophylline and cyclic AMP on sodium transport across isolated frog skin have been studied using 24Na for the measurement of sodium fluxes. Both vasopressin and theophylline produced consistent increases in short-circuit current, sodium influx and efflux, with a reduction in partial resistance of the skin. The same results were obtained with cyclic AMP only when it was combined with small (loses of theophylline which were by themselves ineffective. The similarity of effect of these three compounds on sodium transport mechanisms strengthens the hypothesis that the physiological activity of vasopressin may be mediated by cyclic AMP. |
| Databáze: | OpenAIRE |
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