Thrombogenicity of some biomedical materials: platelet-interface reactions
| Autor: | Kenneth M. Brinkhous, D. Emerson Scarborough, H. G. Clark, James J. Kearney, Sabiha R. Saba, Lynn D. Ikenberry, R. G. Mason |
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| Rok vydání: | 1969 |
| Předmět: |
Blood Platelets
Materials science Polymers Biomedical Engineering Thrombogenicity In Vitro Techniques Biomaterials chemistry.chemical_compound Hemoglobins Adenine nucleotide Polymer chemistry Humans Methyl methacrylate Methyl acrylate Blood Coagulation Acrylic acid chemistry.chemical_classification Ethylene oxide Adenine Nucleotides Heparin Platelet Factor 3 Polymer Microscopy Electron chemistry Acrylates Polyvinyls Adsorption Collagen Rubber Polyethylenes |
| Zdroj: | Journal of biomedical materials research. 3(4) |
| ISSN: | 0021-9304 |
| Popis: | Fifty-eight polymers and other materials were evaluated for compatibility with human blood in an in vitro test system. Assays for platelet factor 3 activation, activation of the coagulation sequences, and release of hemoglobin and adenine nucleotides were performed on blood exposed to each of the 58 test materials. Of the materials tested, collagen, heparinized hydrin rubber, poly (methyl methacrylate), graphite-benzalkonium-heparin, poly (methyl acrylate), isotactic poly(methyl methacrylate), grafted poly (ethylene oxide) on poly (acrylic acid), balata rubber, L-1624 from 3M Co., and chlorinated poly (vinyl chloride) appeared most compatible with blood. Chemical affinities appeared to have little to do with blood compatibility of the materials tested. Electron microscopic examination of blood components adherent to selected test materials following exposure to blood was carried out. Each of the three polymers with “good” and the two polymers with “poor” blood compatibility characteristics which were examined by electron microscopy was coated with a thin unilaminar adsorbate from blood. Platelets and fibrin were focally deposited on this adsorbate. Of the test surfaces examined, only glass was covered by a trilaminar adsorbate. Mechanisms of formation of the adsorbates are discussed. |
| Databáze: | OpenAIRE |
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