A Light‐up Logic Platform for Selective Recognition of Parallel G‐Quadruplex Structures via Disaggregation‐Induced Emission
| Autor: | Marco Deiana, Karam Chand, Jan Jamroskovic, Ikenna Obi, Erik Chorell, Nasim Sabouri |
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| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Chemistry Supramolecular chemistry Nanotechnology General Medicine Biosensing Techniques DNA General Chemistry 010402 general chemistry G-quadruplex 01 natural sciences Catalysis 0104 chemical sciences G-Quadruplexes Dna detection chemistry.chemical_compound Spectrometry Fluorescence Logic gate Humans Light Up Biosensor |
| Zdroj: | Angewandte Chemie International Edition. 59:896-902 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201912027 |
| Popis: | The design of turn-on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G-quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition-driven disaggregation (on-signal) of an ultrabright coumarin-quinazoline conjugate. The synthesized probe selectively lights-up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label-free molecular logic system. Finally, our molecule preferentially stains the G4-rich nucleoli of cancer cells. |
| Databáze: | OpenAIRE |
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