Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study

Autor:	Ahmed Salah, Yasser Sedky, Mohammad M. Sallam, Sahbaa F. M. Hafez, Hany A. A. Elbasyouni, Samar S. Morsi, Mai M. Malek, Maggie M. Fawzi, Mohamed Sayed Fahim, Mayy A.N. Allah, Maa Youssef, Shaimaa S. A. Elashkar, Ahmed Sherif, Mustafa I.A. Hashem, A A Sobeih, Aaa Mosabah, Abdallah Nawara, Elsayed A. Elgohary, Alshymaa A. Ahmed, Mohamed H. Mashali, Mohamed A. Elkoumi, Dalia S. Fahmy, Mohammed Soliman, Adel M. Abdou, Doaa Alhussein Abo-Alella, Heba Gamal Anany, NourEldin M. Abdelaal, Ahmed A. Emam, Mervat T. Zakaria, A M Elshreif, F M El-Deeb
Rok vydání:	2019
Předmět:	0301 basic medicine Male Adolescent Lupus nephritis Potential candidate Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors Lectins medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Prospective Studies Child Gene Alleles 030203 arthritis & rheumatology Autoimmune disease business.industry medicine.disease Lupus Nephritis 030104 developmental biology Logistic Models Multicenter study Case-Control Studies Immunology Egypt Female business Ficolin
Zdroj:	Lupus. 28(8)
ISSN:	1477-0962
Popis:	Background Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. Objectives The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions −986 (G/A), −602 (G/A), −4 (A/G) and SNP C/T (rs3124954) located in intron 1, with susceptibility to pSLE in Egyptian children and adolescents. Methods This was a multicenter study of 280 patients diagnosed with pSLE, and 280 well-matched healthy controls. The FCN2 promoter polymorphisms at –986 G/A (rs3124952), −602 G/A (rs3124953), −4 A/G (rs17514136) and SNP C/T (rs3124954) located in intron 1 were genotyped by polymerase chain reaction, while serum ficolin-2 levels were assessed using enzyme-linked immunosorbent assay. Results The frequencies of the FCN2 GG genotype and G allele at −986 and −602 positions were significantly more represented in patients with pSLE than in controls ( p Conclusion The FCN2 promoter polymorphisms may contribute to susceptibility to pSLE in Egyptian children and adolescents. Moreover, the FCN2 GG genotype at position −986 and AA genotype at position −4 were associated with low serum ficolin-2 levels and may constitute risk factors for lupus nephritis in pSLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d66a4753d90d87e2eb17ca4e0f4aa4d https://pubmed.ncbi.nlm.nih.gov/31184250 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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