The influence of Helicobacter pylori on the level of endotheline-1 and nitrogen oxide in the blood of children with the duodenal ulcer

Autor: Nadiia Chernei, Iryna Sokolnyk, S.V. Sokolnyk, Tаmila Sorokman, Nataliya Oleksandrivna Popelyuk
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 10, Iss 11, Pp 261-272 (2020)
ISSN: 2391-8306
Popis: Sorokman Tаmila, Chernei Nadiia, Sokolnyk Snizhana, Sokolnyk Iryna, Popelyuk Nataliya. The influence of Helicobacter pylori on the level of endotheline-1 and nitrogen oxide in the blood of children with the duodenal ulcer. Journal of Education, Health and Sport. 2020;10(11):261-272. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.11.026 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.11.026 https://zenodo.org/record/4453285 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 16.10.2020. Revised: 30.10.2020. Accepted: 30.11.2020. THE INFLUENCE OF HELICOBACTER PYLORI ON THE LEVEL OF ENDOTHELINE-1 AND NITROGEN OXIDE IN THE BLOOD OF CHILDREN WITH THE DUODENAL ULCER Tаmila Sorokman1, Nadiia Chernei1, Snizhana Sokolnyk1, Iryna Sokolnyk1, Nataliya Popelyuk2 Bukovinian State Medical University, Chernivtsi, Ukraine 1Department of Pediatrics and Medical Genetics Bukovinian State Medical University, Chernivtsi, Ukraine 2Department of Pediatrics, Neonatology and Perinatal Medicine of Bukovinian State Medical University, Chernivtsi, Ukraine Address for correspondence: Sorokman T. Proffesor of the department of Pediatrics and Medical Genetics BSMU, DMS, MD, professor. E-mail: t.sorokmam@gmail.com https://orcid.org/0000-0001-7615-3466 Mobile phone +380506642667; Abstract The most serious pathology of the of gastrointestinal tract in children remains duodenal ulcer (DU). Interesting is the study of the role of endothelin-1 and nitrogen oxide in the formation of DU. The aim. To evaluate the nature of changes in the level of nitrogen oxide (NO) and endothelin-1 (Et-1) in the blood of children with H pylori-associated DU. Methods. A single-center study was conducted in 42 children with DU aged 6–18 years and 20 children comparison group. Diagnostics of H. pylori was performed primary endoscopy and 4 weeks after the end of treatment. Blood samples were collected in each visit to measure plasma Et-1 using an enzyme immunoassay kit and NO (nitrate/nitrite) levels Golikov's method. Results. In 37 (92.5%) the ulcers went through re-epithelialization, while successful eradication of H. pylori was achieved in 32 people (80%). The NO level in the blood plasma of the children of the main group was 9.78 ± 1.13 mmol/l, after treatment –11.09 ± 1.2 mmol/l. After eradication of H. pylori, the level of Et-1 decreased from 2.39 ± 0.08 to 1.14 ± 0.07 pg / ml. Conclusion. Levels of endothelin-1 (Et-1) and nitrogen oxide (NO) in children with duodenal ulcer vary depending on the stage of the disease. After H-pylori eradication, ulcer defect healing is associated with decreased of Et-1 in plasma and increased NO activity. Key words: Children; H. pylori; Duodenal ulcer; Endothelin-1; Nitrogen oxide.
Databáze: OpenAIRE
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