Extraction mechanism of ultrasound assisted extraction and its effect on higher yielding and purity of artemisinin crystals from Artemisia annua L. leaves
| Autor: | Hamid Aït-Amar, Smain Chemat, Omar Arous, Abdenour Boumechhour, Abdallah Aissa |
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| Rok vydání: | 2016 |
| Předmět: |
Yield (engineering)
Acoustics and Ultrasonics Artemisia annua 02 engineering and technology Chemical Fractionation 01 natural sciences law.invention Inorganic Chemistry Adsorption law medicine Chemical Engineering (miscellaneous) Environmental Chemistry Radiology Nuclear Medicine and imaging Artemisinin Crystallization Chromatography biology 010405 organic chemistry Chemistry business.industry Organic Chemistry Ultrasound Temperature 021001 nanoscience & nanotechnology biology.organism_classification Artemisinins 0104 chemical sciences Plant Leaves Activated charcoal Ultrasonic Waves Leaching (metallurgy) 0210 nano-technology business medicine.drug |
| Zdroj: | Ultrasonics sonochemistry. 34 |
| ISSN: | 1873-2828 |
| Popis: | This study proposes an ultrasound-horn system for the extraction of a natural active compound "artemisinin" from Artemisia annua L. leaves as an alternative to hot maceration technique. Ultrasound leaching improves artemisinin recovery at all temperatures where only ten minutes is required to recover 70% (4.42mgg-1) compared to 60min of conventional hot leaching for the same yield. For instance, ultrasound treatment at 30°C produced a higher yield than the one obtained by conventional maceration at 40°C. Kinetic study suggests that the extraction pattern can be assimilated, during the first ten minutes, to a first order steady state, from which activation energy calculations revealed that each gram of artemisinin required 7.38kJ in ultrasound versus 10.3kJ in the conventional system. Modeling results indicate the presence of two extraction stages, a faster stage with a diffusion coefficient of 19×10-5cm2min-1 for ultrasound technique at 40°C, seven times higher than the conventional one; and a second deceleration stage similar for both techniques with diffusion coefficient ranging from 1.7 to 3.1×10-5cm2min-1. It is noted that the efficient ultrasound extraction potential implies extraction of higher amount of co-metabolites so low artemisinin crystal purity is engendered but a combination with a purification step using activated charcoal and celite adsorbents produced crystals with comparable purity for conventional and ultrasound samples. |
| Databáze: | OpenAIRE |
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