Serum lactate dehydrogenase activity in canine malignancies
Autor: | F. Salerni, S. Mazzotti, G. Crispino, Laura Marconato, Eric Zini, Riccardo Finotello |
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Přispěvatelé: | University of Zurich, Marconato, L, Crispino, G, Finotello, R, Mazzotti, S, Salerni, F, Zini, E |
Rok vydání: | 2009 |
Předmět: |
Male
Pathology medicine.medical_specialty 10253 Department of Small Animals 3400 General Veterinary Disease Biology chemistry.chemical_compound Blood serum Dogs Lactate dehydrogenase Neoplasms Dog medicine Carcinoma Biomarkers Tumor Animals Dog Diseases Mast cell tumour General Veterinary L-Lactate Dehydrogenase 630 Agriculture Animal Cancer medicine.disease Lymphoma chemistry 570 Life sciences biology Dog Disease Serum lactate dehydrogenase |
DOI: | 10.5167/uzh-26372 |
Popis: | Lactate dehydrogenase (LDH) is commonly used in human cancer patients for prognostic purposes. Aim of this study was to determine the magnitude of serum LDH elevation in dogs with cancer compared with healthy dogs and dogs with non-neoplastic disease, and to verify whether it may support the diagnosis of specific malignancies. About 128 healthy dogs, 211 diseased dogs and 188 cancer dogs were enrolled. Dogs with cancer had significantly higher LDH than diseased (P < 0.001) and healthy dogs (P < 0.001), but large overlap was found. Dogs with lymphoma showed significantly higher LDH compared with dogs with carcinoma (P < 0.001) or mast cell tumour (MCT; P < 0.05) but not compared with other malignancies. When considering lymphoma and MCT, LDH levels were not different between early and advanced clinical stages. Measuring LDH levels may not be useful as a screening tool for cancer detection. More studies are needed to define its role in specific tumours. |
Databáze: | OpenAIRE |
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