Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
| Autor: | Giuseppe Montalto, Jörg Bäsecke, Ferdinando Nicoletti, Melchiorre Cervello, Maria Clorinda Mazzarino, James A. McCubrey, Alberto M. Martelli, Danijela Maksimović-Ivanić, Massimo Libra, Camilla Evangelisti, Saverio Candido, Paolo Fagone, Sanja Mijatović, Francesca Chiarini, Linda S. Steelman, Grazia Malaponte, Stephen L. Abrams, William H. Chappell, Agostino Tafuri, Michele Milella, Lucio Cocco |
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| Přispěvatelé: | J.A. McCubrey, L.S. Steelman, W.H. Chappell, S.L. Abram, G. Montalto, M. Cervello, F. Nicoletti, P. Fagone, Graziella Malaponte, M.C. Mazzarino, S. Candido, M. Libra, J. Bäsecke, S. Mijatovic, D. Maksimovic-Ivanic, M. Milella, A. Tafuri, L. Cocco, C. Evangelisti, F. Chiarini, A.M. Martelli., McCubrey, JA, Steelman, LS, Chappell, WH, Abrams, SL, Montalto, G, Cervello, M, Nicoletti, F, Fagone, P, Malaponte, G, Mazzarino, MC, Candido, S, Libra, M, Bäsecke, J, Mijatovic, S, Maksimovic-Ivanic, D, Milella, M, Tafuri, A, Cocco, L, Evangelisti, C, Chiarini, F, Martelli, AM |
| Rok vydání: | 2012 |
| Předmět: |
MAPK/ERK pathway
Premature aging MAP Kinase Signaling System Targeted Therapy Therapy Resistance Mutations Raf Akt PI3K mTOR Mtor Reviews Pi3k PI3K Receptor tyrosine kinase Akt Mutations Raf Targeted therapy Therapy resistance Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine Animals Humans PTEN Extracellular Signal-Regulated MAP Kinases Protein kinase B PI3K/AKT/mTOR pathway 030304 developmental biology 0303 health sciences biology Chemistry TOR Serine-Threonine Kinases PTEN Phosphohydrolase Targeted Therapy Therapy Resistance Protein phosphatase 2 MAP Kinase Kinase Kinases 3. Good health Cell biology Oncology 030220 oncology & carcinogenesis Mutation ras Proteins mTOR Cancer research biology.protein raf Kinases Mitogen-Activated Protein Kinases Signal transduction Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Oncotarget Publons ResearcherID |
| ISSN: | 1949-2553 |
| Popis: | The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTEN, TSC1, and TSC2 may also be activated/inactivated by mutations or epigenetic silencing. Upstream mutations in one signaling pathway or even in downstream components of the same pathway can alter the sensitivity of the cells to certain small molecule inhibitors. These pathways have profound effects on proliferative, apoptotic and differentiation pathways. Dysregulation of components of these cascades can contribute to: resistance to other pathway inhibitors, chemotherapeutic drug resistance, premature aging as well as other diseases. This review will first describe these pathways and discuss how genetic mutations and epigenetic alterations can result in resistance to various inhibitors. Italian Ministero dellIstruzione, dellUniversita e della Ricerca (Ministry for Education, Universities and Research) - MIUR [n. RBNE08YYBM]; CNR from Italian Ministry of Economy and Finance for the Project FaReBio di Qualita; MIUR [RBAP10447J-003, RBA |
| Databáze: | OpenAIRE |
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