Outcome of fetuses with short femur length detected at second-trimester anomaly scan: a national survey
Autor: | Mathiesen, J. M., Aksglaede, L., Skibsted, L., Petersen, O. B., Tabor, A., Jørgensen, Finn Stener, Larsen, T., Mogensen, H., Hoseth, Eva, Sommer, Steffen, Sperling, Lene Søndergaard, Zingenberg, Helle, Nørgaard, Lone Nikoline, Jensen, H. S., Farlie, Richard, Østergaard, Marianne, Pouplier, Susanne, Lyngsø, Jane Maria |
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Rok vydání: | 2013 |
Předmět: |
Adult
Down syndrome medicine.medical_specialty Femur/abnormalities Birth weight Denmark Population Aneuploidy Chromosome Disorders Fetus/abnormalities Ultrasonography Prenatal Fetus Pregnancy medicine Humans Radiology Nuclear Medicine and imaging aneuploidy Femur second-trimester malformation scan education Down Syndrome/diagnostic imaging Retrospective Studies Fetal Diseases/diagnostic imaging education.field_of_study Radiological and Ultrasound Technology Chromosome Disorders/diagnostic imaging business.industry Obstetrics Pregnancy Outcome Obstetrics and Gynecology Gestational age General Medicine Odds ratio short femur medicine.disease trisomy 21 Fetal Diseases Reproductive Medicine Karyotyping Pregnancy Trimester Second femur length Female Down Syndrome business Trisomy |
Zdroj: | Mathiesen, J M, Aksglaede, L, Skibsted, L, Petersen, O, Tabor, A, Danish Fetal Medicine Research Group & Sperling, L 2014, ' Outcome of fetuses with short femur length detected at second-trimester anomaly scan : A national survey ', Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 44, no. 2, pp. 160-165 . https://doi.org/10.1002/uog.13286 Mathiesen, J M, Aksglaede, L, Skibsted, L, Petersen, O B, Tabor, A, Jørgensen, F S, Larsen, T, Mogensen, H, Hoseth, E, Sommer, S, Sperling, L S, Zingenberg, H, Nørgaard, L N, Jensen, H S, Farlie, R, Østergaard, M, Pouplier, S & Lyngsø, J M 2014, ' Outcome of fetuses with short femur length detected at second-trimester anomaly scan : A national survey ', Ultrasound in Obstetrics and Gynecology, vol. 44, no. 2, pp. 160-165 . https://doi.org/10.1002/uog.13286 Mathiesen, J M, Aksglaede, L, Skibsted, L, Petersen, O B, Tabor, A & The Danish Fetal Medicine Group 2014, ' Outcome of fetuses with short femur length detected at second-trimester anomaly scan : A national survey ', Ultrasound in Obstetrics & Gynecology, vol. 44, no. 2, pp. 160-165 . https://doi.org/10.1002/uog.13286 |
ISSN: | 1469-0705 |
Popis: | Objective To assess the relationship between the finding of fetal femur diaphysis length (FL) below the 5th percentile at the second-trimester scan and pregnancy outcome, in a population in which more than 90% of women attend first-trimester screening. Methods This was a retrospective study of all Danish singleton pregnancies with a 17–22-week anomaly scan between 1 January 2008 and 30 June 2011. Information on FL and gestational age (GA) at anomaly scan, on birth weight and GA at delivery and on chromosomal abnormalities was obtained from the Danish Fetal Medicine Database. Results Short FL was identified in 2718 (1.8%) of 147 766 fetuses and was present in 11 (16.2%) of the 68 fetuses affected by trisomy 21 (positive likelihood ratio (LR+) 8.8 (95% CI, 5.1–15.2)). Trisomy 13/18 and unbalanced autosomal structural abnormalities were also associated with a short FL in three (12.0%, LR+ 6.5 (95% CI, 2.3–18.9)) and eight (32.0%, LR+ 17.4 (95% CI, 9.8–30.9)) of the cases, respectively. The risk of a fetus having trisomy 21, trisomy 18, trisomy 13 or an unbalanced autosomal structural abnormality was 1 : 123 (95% CI, 79–192), given a short FL. Pregnancies with a fetus with short FL were more often affected by early preterm delivery (before 34 weeks) (5.6%; odds ratio (OR) = 4.2 (95% CI, 3.5–4.9)) and small-for-gestational-age (SGA) infants (13.9%; OR = 4.3 (95% CI, 3.8–4.8)). Conclusion Short FL at the second-trimester anomaly scan is associated with a significantly higher relative risk of chromosomal abnormalities, and a substantially higher absolute risk for SGA and early preterm delivery. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd |
Databáze: | OpenAIRE |
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