Comparison of interferon-γ release assays, QuantiFERON TB-GIT and T-Spot. TB , in renal transplantation
| Autor: | Hidetoshi Igari, K. Otsuki, Kiminori Suzuki, Mizue Tsuyuzaki, Naotake Akutsu, Michihiro Maruyama, Satoru Ishikawa, Fumio Yamagishi, Masayuki Hasegawa, Kenichi Saigo, Hiromichi Aoyama |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Tuberculosis Adolescent QuantiFERON Immunocompromised Host Interferon-gamma Young Adult 03 medical and health sciences 0302 clinical medicine Latent Tuberculosis Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Young adult T-SPOT.TB Kidney transplantation Aged Latent tuberculosis business.industry Middle Aged bacterial infections and mycoses medicine.disease Kidney Transplantation Confidence interval Transplantation Cross-Sectional Studies Infectious Diseases 030228 respiratory system Immunology Female business Interferon-gamma Release Tests |
| Zdroj: | Journal of Infection and Chemotherapy. 23:468-473 |
| ISSN: | 1341-321X |
| Popis: | Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON®-TB Gold in Tube (QFT) and T-SPOT®.TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17-75) were prospectively enrolled, and QFT and TSPOT were concurrently examined. Total subjects were 92 patients (median age 46 years, range 17-75). The positive rate in QFT and TSPOT were 6.5% (95% confidence interval (CI) 3.0-13.5) and 2.2% (95% CI 1.0-7.6), respectively. There was a significant difference in IGRAs positivity (P |
| Databáze: | OpenAIRE |
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