Long-term lorcainide therapy in patients with ventricular tachycardia
| Autor: | David Flowers, Vilma Torres, Dennis S. Miura, Deborah Keefe, Brenda Butler, John C. Somberg |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Drug Lidocaine Heart Ventricles Sedation media_common.quotation_subject Population Benzeneacetamides Procainamide Ventricular tachycardia Lorcainide Electrocardiography Piperidines Tachycardia medicine Humans In patient education media_common education.field_of_study business.industry Cardiac Pacing Artificial Middle Aged medicine.disease Anesthesia Injections Intravenous Drug Evaluation Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Heart Journal. 109:33-40 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(85)90412-0 |
| Popis: | One hundred patients inducible at electrophysiologic studies underwent serial drug testing with procainamide, lidocaine, and lorcainide to determine comparative efficacy. Acute intravenous administration was followed by repeat programmed electrical stimulation (PES) studies on separate days for each antiarrhythmic drug. Lorcainide prevented ventricular tachycardia (VT) induction in 69% of the 100 patients studied, procainamide was effective in 50% of the 75 patients studied, and lidocaine prevented VT induction in 30% of 53 patients. Following PES and serial drug testing, 46 patients were started on lorcainide, nine patients on procainamide, and 45 patients were started on other antiarrhythmic drug regimens. Seventy percent of the patients have remained on lorcainide therapy, while 47% have continued on other drug therapies started over a 20.5 ± 3.2-month mean follow-up period. Despite sleep-wake disturbances and a need for sedation at night, lorcainide therapy was tolerated well in this population and remained an effective antiarrhythmic with prolonged administration. |
| Databáze: | OpenAIRE |
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