Maternal physical activity prevents the overexpression of hypoxia-inducible factor 1-α and cardiorespiratory dysfunction in protein malnourished rats

Autor: Tatiany Patrícia Romão, Viviane Oliveira Nogueira, Luana D. S. Andrade, Carol Góis Leandro, João Henrique Costa-Silva, Palloma Emanuelle Dornelas de Melo, Reginaldo L. Rocha-Junior, Elisama Helvecio, Danilo Augusto Ferreira Fontes
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
Sympathetic Nervous System
Offspring
lcsh:Medicine
Cardiovascular System
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Physical Conditioning
Animal
Internal medicine
Lactation
Diet
Protein-Restricted
medicine
Animals
Humans
Rats
Wistar
lcsh:Science
Nutrition
Carotid Body
Multidisciplinary
Tyrosine hydroxylase
Cholesterol
business.industry
Respiration
lcsh:R
Malnutrition
Purinergic receptor
Albumin
Cardiorespiratory fitness
Maternal Nutritional Physiological Phenomena
Hypoxia-Inducible Factor 1
alpha Subunit
Rats
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Cardiorespiratory Fitness
Gene Expression Regulation
chemistry
Prenatal Exposure Delayed Effects
lcsh:Q
Female
Carotid body
business
030217 neurology & neurosurgery
Zdroj: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
ISSN: 2045-2322
Popis: Maternal physical activity attenuates cardiorespiratory dysfunctions and transcriptional alterations presented by the carotid body (CB) of rats. Rats performed physical activity and were classified as inactive/active. During gestation and lactation, mothers received either normoprotein (NP-17% protein) or low-protein diet (LP-8% protein). In offspring, biochemical serum levels, respiratory parameters, cardiovascular parameters and the mRNA expression of hypoxia-inducible factor 1-alpha (HIF-1α), tyrosine hydroxylase (TH) and purinergic receptors were evaluate. LP-inactive pups presented lower RF from 1st to 14th days old, and higher RF at 30 days than did NP-inactive and NP-active pups. LP-inactive pups presented with reduced serum protein, albumin, cholesterol and triglycerides levels and an increased fasting glucose level compared to those of NP-inactive and NP-active groups. LP and LP-inactive animals showed an increase in the cardiac variability at the Low-Frequency bands, suggesting a major influence of sympathetic nervous activity. In mRNA analyses, LP-inactive animals showed increased HIF-1α expression and similar expression of TH and purinergic receptors in the CB compared to those of NP groups. All these changes observed in LP-inactive pups were reversed in the pups of active mothers (LP-active). Maternal physical activity is able to attenuate the metabolic, cardiorespiratory and HIF-1α transcription changes induced by protein malnutrition.
Databáze: OpenAIRE
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