Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators
| Autor: | Rukiye Dagalp, Canan Kus, Ezgi Ozer, Yesim Korkmaz, Erkan Yurtcu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Imidazopyridine
Antineoplastic Agents Benzamidine Receptors Urokinase Plasminogen Activator chemistry.chemical_compound Inhibitory Concentration 50 Cell Line Tumor Drug Discovery Carcinoma medicine Humans Enzyme Inhibitors Benzamide Receptor Cell Proliferation Pharmacology General Medicine medicine.disease Urokinase-Type Plasminogen Activator Benzamidines Urokinase receptor chemistry Cell culture Benzamides Cancer research Plasminogen activator |
| Zdroj: | Mini reviews in medicinal chemistry. 18(20) |
| ISSN: | 1875-5607 |
| Popis: | BACKGROUND & METHOD In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p |
| Databáze: | OpenAIRE |
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