Lactate is an alternative energy fuel to glucose in neurons under anesthesia
| Autor: | Osamu Inoue, Rie Hosoi, Masatoshi Yamaguchi, Sotaro Momosaki, Natsumi Imamoto, Keisuke Yamamoto, Akifumi Yamada |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pentobarbital Anesthetics General Chloral hydrate Central nervous system Down-Regulation Carbohydrate metabolism chemistry.chemical_compound Mice medicine Animals Carbon Radioisotopes Chloral Hydrate Lactic Acid Rats Wistar Brain Chemistry Cell Death General Neuroscience Brain Quinolinic Acid Lactic acid Rats medicine.anatomical_structure Glucose chemistry Anesthesia Anesthetic Nerve Degeneration Autoradiography Neuron Energy Metabolism medicine.drug Quinolinic acid |
| Zdroj: | Neuroreport. 20(17) |
| ISSN: | 1473-558X |
| Popis: | The uptake of [14C]lactate was measured in the brains of mice anesthetized with pentobarbital or chloral hydrate. The results showed significant increase of the [14C]lactate uptake in the brain under both anesthesia. Despite energy metabolism in the brain being suppressed by both pentobarbital and chloral hydrate, the [14C]lactate uptake was unexpectedly increased under anesthesia. [14C]Lactate uptake in rat brain injured by infusion of quinolic acid was significantly decreased, and the reduction of [14C]lactate uptake was parallel to neural cell death, suggesting that exogenous lactate might be selectively taken up by neuron. These results indicated that lactate rather than glucose might serve as an energy substrate for neuron in intact brain under anesthesia. |
| Databáze: | OpenAIRE |
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