A (1)H NMR spectroscopic study of the biochemical effects of ifosfamide in the rat: evaluation of potential biomarkers
| Autor: | John A. Timbrell, E. M. Lenz, J K Nicholson, I D Wilson |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Kidney
medicine.medical_specialty Ifosfamide Chromatography Health Toxicology and Mutagenesis Clinical Biochemistry Urine Testicle Biochemistry Nitrogen mustard Excretion chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine Toxicity medicine Proton NMR medicine.drug |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 5(6) |
| ISSN: | 1354-750X |
| Popis: | Ifosfamide (55 mg kg(-1) and 110 mg kg(-1)) was administered via single i.p. injections to Sprague-Dawley rats and urine samples were collected for the periods of -24-0, 0-8 h, 8-24 h, 24-48 h and 48-72 h post-dose. Quantitative changes in the excretion pattern of small organic molecules in the urine of rats treated with ifosfamide were studied using high frequency 1H NMR spectroscopy. The kidneys and livers of the animals were also examined, but showed no marked histopathological changes. (1.) |
| Databáze: | OpenAIRE |
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