Palladium catalyzed asymmetric allylic alkylation of isoquinolinedione derivatives in the preparation of quaternary carbon stereocenters

Autor:	Yuan-Yong Yang, Cheng Cheng, Lei Tang, Ying-Xian Li
Rok vydání:	2020
Předmět:	Organic Chemistry Enantioselective synthesis chemistry.chemical_element Biochemistry Catalysis Stereocenter Tsuji–Trost reaction chemistry Asymmetric carbon Organic chemistry Physical and Theoretical Chemistry Vicinal Palladium Quaternary carbon
Zdroj:	Organicbiomolecular chemistry. 18(24)
ISSN:	1477-0539
Popis:	A highly enantioselective allylic alkylation of isoquinolinedione derivatives under palladium catalysis was developed in the preparation of quaternary carbon stereocenters. Under standard reaction conditions, excellent yields and enantioselectivities were realized and the products could be transformed into dihydroisoquinolone with vicinal chiral carbon centers or THIQ core structures in short steps with high yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5b3d3736d57bf1952872cb4dcf00d4 https://pubmed.ncbi.nlm.nih.gov/32484497 Zobrazit plný text záznamu