Differential expression of circulating serum miR-1249-3p, miR-3195, and miR-3692-3p in non-small cell lung cancer
| Autor: | Ashraf Ali, Surender Kumar Sharawat, Sachin Kumar, Sunil Kumar, Vikas Gaur, Randeep Guleria, Anant Mohan, Monu Pandey, Prabhat Singh Malik |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Carcinogenesis medicine.medical_treatment Gene Expression medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Internal medicine microRNA Biomarkers Tumor medicine Humans Prospective cohort study Lung cancer Chemotherapy business.industry Cell Biology medicine.disease MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Adenocarcinoma Cancer biomarkers business |
| Zdroj: | Human Cell. 33:839-849 |
| ISSN: | 1749-0774 |
| DOI: | 10.1007/s13577-020-00351-9 |
| Popis: | Global deregulation in miRNA expression is a hallmark of cancer cell. An estimated 2300 mature miRNAs are encoded by human genome; role of many of which in carcinogenesis and as cancer biomarkers remains unexplored. In this study, we investigated the utility of miR-3692-3p, miR-3195, and miR-1249-3p as biomarkers in non-small cell lung cancer (NSCLC). For this prospective study, 115 subjects, including 75 NSCLC patients and 40 controls, were recruited. The expression of miR-3692-3p, miR-3195, and miR-1249-3p was checked using qRT-PCR. The miRNA expression was correlated with survival outcome and therapeutic response. There were no significant differences in the mean age of NSCLC patients and controls (56.2 and 55.3 years, respectively; p = 0.3242). Majority of NSCLC patients (67%) were smokers. We observed a significant upregulation of miR-3692-3p expression (p |
| Databáze: | OpenAIRE |
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