Near-Infrared Triggered Decomposition of Nanocapsules with High Tumor Accumulation and Stimuli Responsive Fast Elimination
| Autor: | Xiaomin Li, Peiyuan Wang, Areej Abdulkareem Al-Khalaf, Wael N. Hozzein, Qin Li, Fan Zhang, Tiancong Zhao, Dongyuan Zhao |
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| Rok vydání: | 2018 |
| Předmět: |
Photoisomerization
Cell Survival Infrared Rays Surface Properties Mice Nude Nanoparticle 02 engineering and technology 010402 general chemistry medicine.disease_cause Photochemistry 01 natural sciences Catalysis Dissociation (chemistry) Nanocapsules Central Nervous System Neoplasms Mice chemistry.chemical_compound Drug Delivery Systems Cell Line Tumor medicine Animals Humans Particle Size chemistry.chemical_classification Antibiotics Antineoplastic Optical Imaging Glioma General Medicine General Chemistry Polymer 021001 nanoscience & nanotechnology Decomposition 0104 chemical sciences Azobenzene chemistry Doxorubicin Drug Screening Assays Antitumor 0210 nano-technology Ultraviolet |
| Zdroj: | Angewandte Chemie International Edition. 57:2611-2615 |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201711354 |
| Popis: | A near-infrared (NIR) induced decomposable polymer nanocapsule is demonstrated. The nanocapsules are fabricated based on layer-by-layer co-assembly of azobenzene functionalized polymers and up/downconversion nanoparticles (U/DCNPs). When the nanocapsules are exposed to 980 nm light, ultraviolet/visible photons emitted by the U/DCNPs can trigger the photoisomerization of azobenzene groups in the framework. The nanocapsules could decompose from large-sized nanocapsule to small U/DCNPs. Owing to their optimized original size (ca. 180 nm), the nanocapsules can effectively avoid biological barriers, provide a long blood circulation (ca. 5 h, half-life time) and achieve four-fold tumor accumulation. It can fast eliminate from tumor within one hour and release the loaded drugs for chemotherapy after NIR-induced dissociation from initial 180 nm capsules to small 20 nm U/DCNPs. |
| Databáze: | OpenAIRE |
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