Efficacy and safety of daclatasvir plus pegylated-interferon alfa 2a and ribavirin in previously untreated HCV subjects coinfected with HIV and HCV genotype-1: a Phase III, open-label study

Autor:	Natalia Zakharova, Hugo Cheinquer, Peter Ackerman, Dennis Hernandez, Jürgen K. Rockstroh, Mark S. Sulkowski, Christophe Moreno, Gail V. Matthews, Adriano Lazzarin, Federico Pulido, Antonio Rivero, Adrián Gadano, Douglas T. Dieterich, Eric Hughes, Juan Berenguer, Pierre Côté, Zhaohui Liu, Timothy Eley, Walford J. Fessel, Jean-Michel Molina, Patricia Mendez, Juan A. Pineda, Stephanie Noviello, Fiona McPhee
Rok vydání:	2017
Předmět:	Adult Male medicine.medical_specialty Pyrrolidines Daclatasvir Hepatitis C virus HIV Infections Hepacivirus Neutropenia medicine.disease_cause Antiviral Agents Gastroenterology Polyethylene Glycols Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Ribavirin medicine Clinical endpoint Humans 030212 general & internal medicine Adverse effect Aged Hepatology Coinfection business.industry Imidazoles Interferon-alpha virus diseases Valine Hepatitis C Chronic Middle Aged medicine.disease Virology Recombinant Proteins Regimen Treatment Outcome chemistry Concomitant Drug Therapy Combination Female 030211 gastroenterology & hepatology Carbamates business medicine.drug
Zdroj:	Hepatology International. 11:188-198
ISSN:	1936-0541 1936-0533
Popis:	Daclatasvir (DCV) is a potent, pangenotypic, hepatitis C virus (HCV) non-structural protein 5A inhibitor with low potential for drug interactions with antiretroviral therapy (ART). We evaluated the safety and efficacy of DCV plus peginterferon alfa-2a/ribavirin (PegIFN/RBV) in HIV-1/HCV genotype-1-coinfected patients. AI444043 (NCT01471574), an open-label, Phase III, single-arm, response-guided treatment (RGT) study included 301 patients. They received DCV doses of 30, 60 or 90 mg once daily (depending on concomitant ART), plus weight-based RBV (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d55a1546b82a0df013d81a082ae16c8 https://doi.org/10.1007/s12072-017-9788-z Zobrazit plný text záznamu Full text from SpringerLink