Azathioprine Therapy in a Pediatric TPMT-Deficient Patient—Still an Option
| Autor: | L. K. van Rossum, Dennis R Wong, S. A. W. van Moorsel, P. M. Hooymans, N. Bevers, M. Meurs |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Purine-Pyrimidine Metabolism Inborn Errors medicine.medical_specialty Adolescent Metabolite Azathioprine Gastroenterology Drug Hypersensitivity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) Pharmacology Dose-Response Relationship Drug Thiopurine methyltransferase biology business.industry Azathioprine therapy Inflammatory Bowel Diseases Pediatric patient Treatment Outcome chemistry 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology Drug Monitoring business Immunosuppressive Agents medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring. 39:1-4 |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/ftd.0000000000000366 |
| Popis: | We describe the case of a pediatric patient on azathioprine therapy with previously undiagnosed homozygote thiopurine S-methyltransferase (TPMT) deficiency, resulting in myelotoxic thiopurine metabolite levels. The patient was successfully treated with a very low azathioprine dose of 50 mg once a week (4% of standard dose), guided by frequent thiopurine metabolite measurement and a close clinical surveillance. We demonstrate that azathioprine therapy still might be an effective and safe therapeutic option in pediatric thiopurine S-methyltransferase-deficient IBD patients. |
| Databáze: | OpenAIRE |
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