Modeling solid-state transformations occurring in dissolution testing
| Autor: | Jaakko Aaltonen, Timo Laaksonen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Pharmaceutical Science Thermodynamics Crystal growth 02 engineering and technology 030226 pharmacology & pharmacy Dosage form law.invention 03 medical and health sciences 0302 clinical medicine Drug Stability Theophylline law Computer Simulation Dissolution testing Solubility Crystallization Dissolution Supersaturation Recrystallization (metallurgy) Models Theoretical 021001 nanoscience & nanotechnology Crystallography Pharmaceutical Preparations Solvents sense organs 0210 nano-technology |
| Zdroj: | International Journal of Pharmaceutics. 447:218-223 |
| ISSN: | 0378-5173 |
| Popis: | Changes in the solid-state form can occur during dissolution testing of drugs. This can often complicate interpretation of results. Additionally, there can be several mechanisms through which such a change proceeds, e.g. solvent-mediated transformation or crystal growth within the drug material itself. Here, a mathematical model was constructed to study the dissolution testing of a material, which undergoes such changes. The model consisted of two processes: the recrystallization of the drug from a supersaturated liquid state caused by the dissolution of the more soluble solid form and the crystal growth of the stable solid form at the surface of the drug formulation. Comparison to experimental data on theophylline dissolution showed that the results obtained with the model matched real solid-state changes and that it was able to distinguish between cases where the transformation was controlled either by solvent-mediated crystallization or solid-state crystal growth |
| Databáze: | OpenAIRE |
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