Poststenotic Flow Disturbance in the Dog Aorta as Measured With Pulsed Doppler Ultrasound
| Autor: | Don P. Giddens, N. Talukder, J. T. Fulenwider, R.F. Mabon |
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| Rok vydání: | 1986 |
| Předmět: |
Frequency response
Materials science business.industry Ultrasound Biomedical Engineering Hemodynamics Aortic Valve Stenosis Blood flow Vortex symbols.namesake Dogs Physiology (medical) symbols Animals Waveform Sensitivity (control systems) Rheology business Doppler effect Blood Flow Velocity Biomedical engineering |
| Zdroj: | Journal of Biomechanical Engineering. 108:259-265 |
| ISSN: | 1528-8951 0148-0731 |
| DOI: | 10.1115/1.3138612 |
| Popis: | Blood flow velocity was measured in the dog aorta distal to mechanically induced constrictions of various degrees of severity employing an 8-MHz pulsed Doppler ultrasound velocimeter and a phase-lock loop frequency tracking method for extracting velocity from the Doppler quadrature signals. The data were analyzed to construct ensemble average velocity waveforms and random velocity disturbances. In any individual animal the effect of increasing the degree of stenosis beyond approximately 25 percent area reduction was to produce increasing levels of random velocity disturbance. However, variability among animals was such that the sensitivity of random behavior to the degree of stenosis was degraded to the point that it appears difficult to employ Doppler ultrasound measurements of random disturbances to discriminate among stenoses with area reductions less than approximately 75 percent. On the other hand, coherent vortex structures in velocity waveforms consistently occurred distal to mild constrictions (25–50 percent area reduction). Comparison of the phase-lock loop Doppler ultrasound data with simultaneous measurements using invasive hot-film anemometry, which possesses excellent frequency response, demonstrates that the ultrasound method can reliably detect those flow phenomena in such cases. Thus, the identification of coherent, rather than random, flow disturbances may offer improved diagnostic capability for noninvasively detecting arteriosclerotic plaques at relatively early stages of development. |
| Databáze: | OpenAIRE |
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