Seroprevalence of EV-A71 neutralizing antibodies following the 2011 epidemic in HCMC, Vietnam
| Autor: | Le Quoc Thinh, Wan-Yu Chung, Le Nguyen Thanh Nhan, Truong Huu Khanh, Wen-Chiung Chang, Fang-Lin Kuo, Shu-Ting Luo, Nguyen Thanh Hung, Min-Shi Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Viral Diseases Pulmonology Physiology Epidemiology RC955-962 Antibodies Viral Biochemistry Geographical Locations 0302 clinical medicine Seroepidemiologic Studies Arctic medicine. Tropical medicine Immune Physiology Medicine and Health Sciences Medicine Neutralizing antibody Child Immune System Proteins biology Foot-and-mouth disease Infectious Diseases Vietnam Child Preschool language Female Public aspects of medicine RA1-1270 Research Article Asia Patients Adolescent Vietnamese 030231 tropical medicine Immunology Taiwan Antibodies Infectious Disease Epidemiology 03 medical and health sciences Antigenic variation Seroprevalence Humans Disease burden Inpatients business.industry Public Health Environmental and Occupational Health Infant Newborn Biology and Life Sciences Proteins Infant medicine.disease Virology Antibodies Neutralizing language.human_language Enterovirus A Human Health Care 030104 developmental biology Vaccination policy People and Places Respiratory Infections biology.protein business Hand Foot and Mouth Disease |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008124 (2020) |
| ISSN: | 1935-2735 1935-2727 |
| Popis: | Enterovirus-A71 (EV-A71) cyclically causes hand-foot-mouth disease (HFMD) epidemics in Asian children. An EV-A71 epidemic occurred in Southern Vietnam in 2011, but its scale is not clear. We collected residual sera from non-HFMD Vietnamese inpatients in 2012–2013 to determine seroprevalence of EV-A71 neutralizing antibodies, and measured cross-reactive neutralizing antibody titers against three EV-A71 genogroups. About 23.5% of 1-year-old children in Southern Vietnam has been infected by EV-A71, and the median age of infection was estimated to be 3 years. No significant antigenic variation could be detected among the three EV-A71 genogroups. The high seroprevalence of EV-A71 neutralizing antibody in children living in southern Vietnam indicates the necessity of introducing EV-A71 vaccines in southern Vietnam, particularly for children under 6 months of age. Moreover, it is critical to understand EV-A71 disease burden for formulating national vaccination policy. Author summary Enterovirus-A71 (EV-A71), a member of the enterovirus genus, is a virulent pathogen causing neurological complications. EV-A71 mainly spreads through oral-fecal or oral-oral transmission, as well as respiratory droplets. EV-A71 outbreaks have cyclically occurred throughout some Asian countries since 1997, with millions of people affected. The presence of serum neutralizing antibodies to EV-A71 can represent the prevalence of previous EV-A71 infections and seroprevalence studies are widely used to understand prevalence of infectious diseases. The results of our study demonstrate that about 50% of young children under 3 years of age were infected during the 2011 epidemic in southern Vietnam. The high seroprevalence of EV-A71 neutralizing antibody in children living in southern Vietnam indicates the necessity of introducing EV-A71 vaccines, particularly for children under 6 months of age. Moreover, it is critical to understand EV-A71 disease burden for formulating national vaccination policy in the future. |
| Databáze: | OpenAIRE |
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