Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay
| Autor: | Leanne M. Flahr, John Gulotta, Darin D. Wallentine, Sally R. Littau, Christiane Hoppe-Jones, Jefferey L. Burgess, Paul K. Moore, Shane A. Snyder, Shawn C. Beitel |
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| Přispěvatelé: | Nanyang Environment and Water Research Institute |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
010504 meteorology & atmospheric sciences
Polycyclic aromatic hydrocarbon Air Pollutants Occupational Urine 010501 environmental sciences 01 natural sciences Occupational Exposure Humans CALUX Bioassay Medicine Polycyclic Aromatic Hydrocarbon Polycyclic Aromatic Hydrocarbons lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 chemistry.chemical_classification business.industry Contamination Environmental engineering::Hazardous substances [Engineering] chemistry Firefighters Environmental chemistry Toxicity Biological Assay business Potential toxicity |
| Zdroj: | Environment International, Vol 135, Iss, Pp-(2020) |
| Popis: | Firefighters can be exposed to a complex set of contaminants while at a fire scene. Identifying new ways to monitor and assess exposure, particularly relating to toxicity is essential to determine the effectiveness of intervention techniques to reduce exposure. This study investigated the use of the polycyclic aromatic hydrocarbon (PAH) CALUX® bioassay for the assessment of exposure and associated toxicity firefighters might encounter. This was done through analysis of extracts of dermal wipes and urine samples collected from firefighters before and after a controlled fire. An increased bioassay response was observed from post-fire neck and calf samples, indicating a greater concentration of PAH-like compounds on the skin. The use of a baby wipe to clean the face and neck during rehab resulted in the attenuation of the observed bioassay response from the neck post-fire. Though a correlation was observed between the bioassay response and hydroxylated PAH concentrations found in the urine, the increased bioassay response from the post-fire urine samples was likely due to unknown compounds other than the hydroxylated PAHs tested. Our results suggest that this bioassay provides a useful measure of firefighter exposure, particularly relating to the potential toxicity of contaminants. Published version his study was funded by the Federal Emergency ManagementAgency,grantnumberEMW-2014-FP-00200. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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