Enantioselective allylic hydroxylation of ω-alkenoic acids and esters by P450 BM3 monooxygenase

Autor:	Birgit Henßen, Katharina Neufeld, Jörg Pietruszka
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Allylic rearrangement Chemistry organic chemicals Enantioselective synthesis Stereoisomerism Biological activity Esters General Chemistry Monooxygenase Alkenes Hydroxylation Catalysis chemistry.chemical_compound Enzyme Organic chemistry Oxidation-Reduction
Zdroj:	Angewandte Chemie (International ed. in English). 53(48)
ISSN:	1521-3773
Popis:	Chiral allylic alcohols of ω-alkenoic acids and derivatives thereof are highly important building blocks for the synthesis of biologically active compounds. The direct enantioselective C-H oxidation of linear terminal olefins offers the shortest route toward these compounds, but known synthetic methods are limited and suffer from low selectivities. Described herein is an enzymatic approach using the P450 BM3 monooxygenase mutant A74G/L188Q, which catalyzes allylic hydroxylation with high to excellent chemo- and enantioselectivities providing the desirable secondary alcohols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d490706e4870a249228863275b48f66 https://pubmed.ncbi.nlm.nih.gov/25164074 Zobrazit plný text záznamu Plný text