MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats
| Autor: | Scott J. Russo, Charles E. Inturrisi, Shirzad Jenab, Eugene D. Festa, Vanya Quinones-Jenab, Hui Bing K. Wu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Proto-Oncogene Proteins c-fos Dynorphin c-Fos Dynorphins Drug Administration Schedule Cellular and Molecular Neuroscience Cocaine Internal medicine medicine Animals Drug Interactions RNA Messenger Anesthetics Local Protein Precursors Molecular Biology biology Putamen Rats Inbred F344 Rats Endocrinology Dizocilpine maleate Mrna level Gene Expression Regulation biology.protein NMDA receptor Dizocilpine Maleate Excitatory Amino Acid Antagonists |
| Zdroj: | Brain research. Molecular brain research. 117(2) |
| ISSN: | 0169-328X |
| Popis: | This study shows that single (15 mg/kg) or binge (3×15 mg/kg) cocaine administration increases c-fos mRNA levels, but only binge cocaine administration increases preprodynorphin mRNA levels in the caudate/putamen of Fischer rats. This increase in both c-fos and preprodynorphin mRNA levels is attenuated by the noncompetitive NMDA antagonist MK-801 (0.25 mg/kg), suggesting a preferential role for NMDA receptor co-activation in cellular events leading to cocaine-induced behaviors. |
| Databáze: | OpenAIRE |
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