Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes

Autor: Gerjan Navis, Christian Delles, Goce Spasovski, Matias Trillini, R. Göke, Lidmila Francová, Marie Frimodt-Møller, Giel Nijpels, I. Dimos, P. Girman, Alberto Ortiz, H. von der Leyen, T. Havrdova, Joline W. Beulens, Marina Noutsou, Peter Rossing, K. Adamova, Andreas L. Birkenfeld, Frederik Persson, Harald Mischak, Ivan Rychlik, Aneliya Parvanova, Marijn M. Speeckaert, Morten Lindhardt, Piero Ruggenenti, Joachim Beige, Nete Tofte, Femke Rutters, Gemma Currie, Adriaan Kooy
Přispěvatelé: Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Value, Affordability and Sustainability (VALUE), Epidemiology and Data Science, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, General practice, APH - Aging & Later Life, ACS - Diabetes & metabolism
Rok vydání: 2018
Předmět:
Adult
Male
Proteomics
CHRONIC KIDNEY-DISEASE
BIOMARKER
medicine.medical_specialty
Adolescent
Proteome
PREDICTION
Endocrinology
Diabetes and Metabolism
Population
030232 urology & nephrology
Renal function
Type 2 diabetes
Urinalysis
030204 cardiovascular system & hematology
DIAGNOSIS
Risk Assessment
Diabetic nephropathy
Young Adult
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
media_common.cataloged_instance
Diabetic Nephropathies
European union
education
Aged
Mineralocorticoid Receptor Antagonists
media_common
education.field_of_study
business.industry
MICROALBUMINURIA
PEPTIDES
Middle Aged
Prognosis
medicine.disease
Diabetes Mellitus
Type 2
Female
Microalbuminuria
Risk assessment
business
Zdroj: Diabetic Med. 35, 1375-1382 (2018)
Tofte, N, Lindhardt, M, Adamova, K, Beige, J, Beulens, J W J, Birkenfeld, A L, Currie, G, Delles, C, Dimos, I, Francová, L, Frimodt-Møller, M, Girman, P, Göke, R, Havrdova, T, Kooy, A, Mischak, H, Navis, G, Nijpels, G, Noutsou, M, Ortiz, A, Parvanova, A, Persson, F, Ruggenenti, P L, Rutters, F, Rychlík, I, Spasovski, G, Speeckaert, M, Trillini, M, von der Leyen, H & Rossing, P 2018, ' Characteristics of high-and low-risk individuals in the PRIORITY study : urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes ', Diabetic Medicine, vol. 35, no. 10, pp. 1375-1382 . https://doi.org/10.1111/dme.13669
Diabetic Medicine, 35(10), 1375-1382. Wiley
Diabetic Medicine, 35(10), 1375-1382. Wiley-Blackwell
ISSN: 0742-3071
0204-0441
Popis: Aim: \ud To compare clinical baseline data in individuals with Type 2 diabetes and normoalbuminuria, who are at high or low risk of diabetic kidney disease based on the urinary proteomics classifier CKD273.\ud \ud Methods: \ud We conducted a prospective, randomized, double‐blind, placebo‐controlled international multicentre clinical trial and observational study in participants with Type 2 diabetes and normoalbuminuria, stratified into high‐ or low‐risk groups based on CKD273 score. Clinical baseline data for the whole cohort and stratified by risk groups are reported. The associations between CKD273 and traditional risk factors for diabetic kidney disease were evaluated using univariate and logistic regression analysis.\ud \ud Results: \ud A total of 1777 participants from 15 centres were included, with 12.3% of these having a high‐risk proteomic pattern. Participants in the high‐risk group (n=218), were more likely to be men, were older, had longer diabetes duration, a lower estimated GFR and a higher urinary albumin:creatinine ratio than those in the low‐risk group (n=1559, P
Databáze: OpenAIRE
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