The nondigestible fat sucrose polyester does not stimulate gallbladder emptying in humans
| Autor: | M.I.M. Maas, Wim P.M. Hopman, Martijn B. Katan, J. B. M. J. Jansen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Sucrose medicine.medical_specialty Gallbladder Emptying medicine.medical_treatment Medicine (miscellaneous) Nutrition secretion and motility chemistry.chemical_compound Dietary Fats Unsaturated Voeding secretie en motoriek Internal medicine medicine Humans Ingestion Fat Substitutes Saline Cholecystokinin Cross-Over Studies Nutrition and Dietetics Gallbladder Fatty Acids Carbohydrate Dietary Fats Crossover study Kinetics medicine.anatomical_structure Endocrinology chemistry Digestion Female |
| Zdroj: | The American Journal of Clinical Nutrition, 68, pp. 1272-1276 The American Journal of Clinical Nutrition, 68, 1272-1276 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/68.6.1272 |
| Popis: | Background: We determined the effect of oral ingestion of sucrose polyester, which was approved as a fat replacer in the United States, on gallbladder motility and on the release of cholecystokinin, the hormone that mediates gallbladder emptying. Objective: Our objective was to measure effects of sucrose polyester on gallbladder emptying and cholecystokinin release. Design: Eight healthy volunteers (3 men and 5 women) drank 60 mL sucrose polyester, digestible fat, or saline solution in a balanced crossover design on 3 separate days. Results: Mean (∠ SEM) gallbladder emptying, when integrated over time, was low in response to both sucrose polyester (2150 ∠ 214 mL · 120 min) and saline solution (289 ∠ 123 mL · 120 min). In contrast, there was marked emptying in response to digestible fat (1069 ∠ 253 mL · 120 min). Sucrose polyester did not affect plasma cholecystokinin concentrations (29.3 ∠ 15.0 pmol · 120 min/L), whereas digestible fat resulted in a significant increase (89.5 ∠ 44.8 pmol · 120 min/L, P = 0.014) compared with saline solution (23.0 ∠ 13.8 pmol · 120 min/L). Conclusions: Ingestion of sucrose polyester, in contrast with digestible fat, did not stimulate gallbladder emptying or release of cholecystokinin. Am J Clin Nutr 1998;68:1272‐5. |
| Databáze: | OpenAIRE |
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