Trends and health burden of hospitalized acute respiratory infections and impact of Haemophilus influenza immunization in a Tunisian university hospital: a twelve-year study
| Autor: | H. Abroug, Aicha Gardabou, Naceur Rouatbi, W Dhouib, Imen Zemni, Manel Ben Fredj, A. Sriha, M Kacem, Slaheddine Chouchene, Koubaa Jamel, Cyrine Bennasrallah, Ons Mehrez |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics Vaccination Coverage Respiratory Infection lcsh:Medicine Hib vaccine burden Global Burden of Disease inpatients 0302 clinical medicine 030212 general & internal medicine Respiratory system Child trends pneumonia Tunisia Respiratory Tract Infections Haemophilus Vaccines Academic Medical Centers biology Respiratory infection General Medicine Middle Aged University hospital Community-Acquired Infections Hospitalization Child Preschool Acute Disease Female Research Article Adult medicine.medical_specialty Adolescent Article Influenza immunization Young Adult 03 medical and health sciences Influenza Human Haemophilus medicine Humans Retrospective Studies business.industry lcsh:R Infant Newborn Infant medicine.disease biology.organism_classification Pneumonia business 030217 neurology & neurosurgery |
| Zdroj: | The Libyan Journal of Medicine article-version (VoR) Version of Record Libyan Journal of Medicine; Vol. 15 No. 1 (2020) Libyan Journal of Medicine, Vol 15, Iss 1 (2020) |
| ISSN: | 1819-6357 1993-2820 |
| DOI: | 10.1080/19932820.2020.1783048 |
| Popis: | Background: We aimed to describe the episodes and trends of admissions for community-acquired Respiratory Infections (RI) over a 12-year period and to assess the impact of Haemophilus influenza type b (Hib) vaccine on RI admissions in children aged up to 3 years. Methods: We conducted a twelve-year retrospective observational study on all community-acquired RI admitted to Fattouma Bourguiba Hospital in Monastir Governorate (Tunisia) from 1 January 2002 to 31 December 2013. RI cases were selected from the Regional Registry of Hospital Morbidity. Data were coded according to ICD-10. To assess the impact of the Hib vaccine, three cohorts were defined based on vaccine status (unvaccinated cohort, first vaccinated cohort (VC) by monovalent form and second VC by pentavalent combination). Results: Admissions for RI represented 17.6% (CI95%: 17.3–18.1) of all communicable diseases hospitalizations (n = 6 061/34 289). The crude incidence rates (CIR) per 100,000 inh were 24.2 for upper RI (URI) and 77.5 and for Lower RI (LRI) (p < 0.0001). Pneumonias represented 53.9% of LRI. Sex-ratio (male/female) was 1.12 for URI and 1.64 for LRI (p < 0.0001). At admission, the median age was 22 years (IQR: 3–52). Admission for Pneumonia increased significantly during study period (slope ‘b’ = 5.16; p < 0.0001) especially in children up to 5 years old (slope ‘b’ = 5.53) and in elderly (slope ‘b’ = 2.13). Among children up to 3 years old, the CIRs per 100,000 for Hib pneumonia admission were 11.6 in Non-Vaccinated Cohort (NVC), 10.6 in Vaccinated Cohort (VC) by protocol 1 (Hib Vaccine monovalent) and 0.80 in VC by protocol 2 (pentavalent vaccine combination).The relative risk reduction was 99% for protocol 2 (p < 0.001). Conclusion: Admissions for RI in a tertiary level hospital were common with an increasing trend. The Hib immunization program, in particular the pentavalent combination, has had a positive impact on the reduction of related acute diseases. |
| Databáze: | OpenAIRE |
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