Effect of altitude on brain intracellular pH and inorganic phosphate levels
| Autor: | Seong Eun Kim, Tae Suk Kim, Perry F. Renshaw, Chun S. Zuo, Breanna Glaeser, Paul J. Carlson, Kristina Wang, Xianfeng Shi, Kristen K. Fiedler, Douglas G. Kondo, Young Hoon Sung, Tracy L. Hellem, Eun Kee Jeong |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Alkalosis Metabolite Intracellular pH Neuroscience (miscellaneous) Contrast Media chemistry.chemical_element Article Phosphates chemistry.chemical_compound Altitude Reference Values Utah Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Acidosis Phosphorus Brain Phosphorus Isotopes Hydrogen-Ion Concentration Hypoxia (medical) Phosphate medicine.disease Psychiatry and Mental health Endocrinology Massachusetts chemistry Female medicine.symptom |
| Zdroj: | Psychiatry Research: Neuroimaging. 222:149-156 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2014.04.002 |
| Popis: | Normal brain activity is associated with task-related pH changes. Although central nervous system syndromes associated with significant acidosis and alkalosis are well understood, the effects of less dramatic and chronic changes in brain pH are uncertain. One environmental factor known to alter brain pH is the extreme, acute change in altitude encountered by mountaineers. However, the effect of long-term exposure to moderate altitude has not been studied. The aim of this two-site study was to measure brain intracellular pH and phosphate-bearing metabolite levels at two altitudes in healthy volunteers, using phosphorus-31 magnetic resonance spectroscopy (31P-MRS). Increased brain pH and reduced inorganic phosphate (Pi) levels were found in healthy subjects who were long-term residents of Salt Lake City, UT (4720 ft/1438 m), compared with residents of Belmont, MA (20 ft/6 m). Brain intracellular pH at the altitude of 4720 ft was more alkaline than that observed near sea level. In addition, the ratio of inorganic phosphate to total phosphate signal also shifted toward lower values in the Salt Lake City region compared with the Belmont area. These results suggest that long-term residence at moderate altitude is associated with brain chemical changes. |
| Databáze: | OpenAIRE |
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