The NCCN Criterion 'Young Age at Onset' Alone is Not an Indicator of Hereditary Breast Cancer in Iranian Population
| Autor: | Elmira Ebrahimi, Reza Ghiasvand, Iraj Harirchi, Kazem Zendehdel, Mohammad R. Akbari, Elham Mohebbi, Erin Sellars, Reza Shirkoohi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty PALB2 Population Breast Neoplasms Iran Iranian population Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Mutation Rate Neoplastic Syndromes Hereditary Internal medicine Humans Medicine Genetic Predisposition to Disease Genetic Testing Age of Onset skin and connective tissue diseases education Germ-Line Mutation Genetic testing BRCA2 Protein education.field_of_study medicine.diagnostic_test BRCA1 Protein business.industry Pathogenic mutation Carcinoma Ductal Breast High-Throughput Nucleotide Sequencing Middle Aged Prognosis medicine.disease Carcinoma Lobular Young age 030104 developmental biology 030220 oncology & carcinogenesis Female Fanconi Anemia Complementation Group N Protein business Follow-Up Studies Hereditary Breast Cancer |
| Zdroj: | Cancer Prevention Research. 12:763-770 |
| ISSN: | 1940-6215 1940-6207 |
| Popis: | Because the contribution of genetic factors to the burden of breast cancer is not well investigated in Iran, we aimed to examine the prevalence of mutations in breast cancer susceptibility genes, BRCA1/2 and PALB2, and to investigate the predictive potential of hereditary breast cancer risk criteria for genetic testing in Iranian population. Next-generation sequencing was conducted on a population consisting of 299 and 125 patients with breast cancer, with and without hereditary cancer risk criteria for genetic testing, respectively. The pathogenic mutation frequency rate was 10.7% in patients with hereditary cancer criteria versus 1.6% in no criteria group (P = 0.0017). None of the 107 tested patients with only young age at onset ( |
| Databáze: | OpenAIRE |
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