Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs
| Autor: | Gregory C. Fu, Sunghee Son |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Allylic rearrangement
Alkylation Lactams Molecular Structure Negishi coupling chemistry.chemical_element Regioselectivity Total synthesis Stereoisomerism General Chemistry Alkenes Biochemistry Combinatorial chemistry Catalysis Zinc Nickel Colloid and Surface Chemistry chemistry Hydrocarbons Chlorinated Organometallic Compounds Organic chemistry |
| Zdroj: | Journal of the American Chemical Society. 130:2756-2757 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja800103z |
| Popis: | Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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