Myocardial antioxidant defenses during cardiopulmonary bypass
| Autor: | Carmine Di Ilio, Andrea Mezzetti, Paolo Santarelli, G Bosco, Domenico Lapenna, Gabriele Di Giammarco, Antonio M. Calafiore, Sante D. Pierdomenico, Franco Cuccurullo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Antioxidant Time Factors medicine.medical_treatment Glutathione reductase Ischemia Coronary Disease medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants law.invention Superoxide dismutase law Internal medicine medicine TBARS Cardiopulmonary bypass Humans Heart Atria Sulfhydryl Compounds Glutathione Transferase chemistry.chemical_classification Glutathione Peroxidase Cardiopulmonary Bypass biology business.industry Superoxide Dismutase Glutathione peroxidase Myocardium Middle Aged medicine.disease Catalase Glutathione Reductase chemistry biology.protein Cardiology Heart Arrest Induced Surgery Cardiology and Cardiovascular Medicine business Oxidative stress |
| Zdroj: | Journal of cardiac surgery. 8(2) |
| ISSN: | 0886-0440 |
| Popis: | In 31 male patients undergoing coronary bypass surgery who underwent different periods of cardioplegic hypothermic arrest, the activities of glutathione peroxidase, glutathione reductase, glutathione transferase, copper/zinc-containing and manganese-containing superoxide dismutases, and catalase were studied in the right atrial myocardium, before and 5 minutes after aortic cross-clamping. The levels of thiobarbituric acid reactive substances (TBARS) and nonproteic thiol compounds (NP-SH) were also assessed. Prolonged ischemia followed by reperfusion induced activation of the major myocardial antioxidant enzymes with marked NP-SH depression and TBARS increase, despite cold crystalloid cardioplegic protection. These changes were significantly related to the duration of the ischemic arrest, suggesting: (1) that reperfusion free radical generation is dependent on the severity of the previous ischemic period; and (2) the occurrence of myocardial oxidative stress during cardiopulmonary bypass. |
| Databáze: | OpenAIRE |
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