Syntheses of 2, 5-Dialkylfuran and Tetrahydrofuran Carbinols and Their Cytotoxic Activity
| Autor: | Jürgen Krauss, Doris Unterreitmeier, Dorothee Antlsperger |
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| Rok vydání: | 2003 |
| Předmět: |
Tetracycline
Grignard reaction Tetrazolium Salts Pharmaceutical Science Antineoplastic Agents Microbial Sensitivity Tests Ring (chemistry) Furfural Chemical synthesis chemistry.chemical_compound Furan Drug Discovery medicine Tumor Cells Cultured Humans Organic chemistry MTT assay Furans Tetrahydrofuran biology Bacteria Methanol General Medicine biology.organism_classification Antimicrobial Thiazoles chemistry Annonaceae Acetogenin Indicators and Reagents Drug Screening Assays Antitumor Aliphatic compound medicine.drug |
| Zdroj: | Archiv der Pharmazie. 336:381-384 |
| ISSN: | 1521-4184 0365-6233 |
| Popis: | 2, 5-Dialkylfuran and tetrahydrofuran compounds as structural elements of Annonaceae acetogenins like Asitrocinwere synthesized starting from furfural by Grignard reactions, lithiation of the furan ring and addition of aliphatic aldehydes. Hydrogenation of the furan rings over Pd-catalyst gave the corresponding tetrahydrofurans. All resulting compounds showed no or rather less antimicrobial activity against grampositive, gram-negative bacteria and fungi compared to tetracycline or clotrimazol but high cytotoxic activity against HL 60 cell line determined in the MTT assay. |
| Databáze: | OpenAIRE |
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