Methadone and Metabolites in Hair of Methadone-Assisted Pregnant Women and Their Infants
| Autor: | Colleen Rock, Rolley E. Johnson, Diana G. Wilkins, Sarah K. Himes, Marilyn A. Huestis, Hendrée E. Jones, Robert S. Goodwin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Metabolite Article Young Adult chemistry.chemical_compound Pharmacotherapy Pregnancy Opiate Substitution Treatment medicine Humans Pharmacology (medical) Young adult Pharmacology business.industry Obstetrics Infant Newborn Opioid-Related Disorders Methadone dose medicine.disease Prenatal Exposure Delayed Effects chemistry Anesthesia Female business Neonatal Abstinence Syndrome Methadone Hair medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring. 34:337-344 |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/ftd.0b013e3182512b26 |
| Popis: | Methadone is the recommended pharmacotherapy for opioid-dependent pregnant women. The primary aims of this study were to determine whether a dose-concentration relationship exists between cumulative maternal methadone dose, methadone and metabolite concentrations in maternal hair during pregnancy and whether maternal hair methadone and metabolite concentrations predict neonatal outcomes.Hair specimens were collected monthly from opioid-dependent mothers enrolled in methadone treatment and 4 of their infants. Hair specimens were segmented (3 cm), washed (maternal hair only), and analyzed for methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-ethyl-5-methyl-3,3-diphenylpyrroline by liquid chromatography tandem mass spectrometry.There was large intersubject variability and no dose-concentration relationship for cumulative methadone dose and methadone, EDDP, 2-ethyl-5-methyl-3,3-diphenylpyrroline, or total concentrations in hair. For individual women, a positive trend was noted for cumulative methadone dose and methadone and EDDP concentrations in hair. There was a positive linear trend for cumulative methadone dose and EDDP/methadone ratio in maternal hair, perhaps reflecting methadone's induction of its own metabolism. Maternal methadone concentrations were higher than those in infant hair, and infant EDDP hair concentrations were higher than those in maternal hair. Maternal methadone dose, and methadone and EDDP hair concentrations were not correlated with peak infant neonatal abstinence syndrome (NAS) scores, days to peak NAS, duration of NAS, time to NAS onset, birth length, head circumference, or amount of neonatal morphine pharmacotherapy. Maternal cumulative third trimester methadone dose was positively correlated with infant birth weight.Methadone and EDDP in pregnant women's hair are markers of methadone exposure and do not predict total methadone dose, nor neonatal outcomes from in utero methadone exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|