The probability of response after each subcutaneous injection of esketamine in treatment-resistant depression

Autor: Juliana Surjan, Lorena Catarina Del Sant, Ana Cecília Lucchese, Andrea Parolin Jackowski, Carolina Nakahira, Hugo Cogo-Moreira, Matheus Ghossain Barbosa, Guilherme Abdo, Acioly L.T. Lacerda, Rodrigo Simonini Delfino, Luciana Maria Sarin, Marco Aurélio Tuena, Matheus Souza Steiglich, Victor Augusto Rodovalho Fava, José Alberto Del Porto, Eduardo Magalhães
Rok vydání: 2020
Předmět:
Zdroj: Revista de psiquiatria y salud mental.
ISSN: 2173-5050
Popis: Introduction The administration of multiple esketamine doses has shown efficacy for unipolar and bipolar treatment-resistant depression (TRD). Nevertheless, the probability of responding or not after each dose in the real-world remains unknown. This study aimed to estimate it throughout four doses of esketamine, administrated via subcutaneous (SC). Material and methods We conducted a retrospective analysis of a case series of 70 patients with TRD who received treatment from the esketamine assistance program at Federal University of Sao Paulo, between April 2017 and December 2018. The SC injections were administrated weekly at a dose of 0.5–1.0 mg/kg, in conjunction with patients’ psychotropic drugs. Response was defined as a decrease of at least 50% in the Montgomery-Asberg Depression Rating Scale between baseline and 24 h after dose. We used hidden Markov modeling in order to estimate de probability of response after each esketamine injection. Results The probability of a patient that was a “non-responder” to become a “responder” following a SC injection of esketamine was 17.30% and the probability that this patient remains a “non-responder” was 82.70%. The probability of a patient that was a “responder” to remain as a “responder” was 95%. Conclusions Patients with TRD who had not responded after the first dose of esketamine, still had a chance of responding after the subsequent dose administrated via SC.
Databáze: OpenAIRE
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