Levofloxacin and furazolidone induced toxic epidermal necrosis
| Autor: | Arup Kumar Misra, Sushil Kumar Varma, Shanta Das Sutradhar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Furazolidone Cytotoxicity hypersensitivity reaction Pharmacology Drug Watch Dexamethasone Pathogenesis Immune system toxic epidermal necrolysis Anti-Infective Agents Levofloxacin medicine Humans Pharmacology (medical) Aged levofloxacin business.industry biochemical phenomena metabolism and nutrition medicine.disease Toxic epidermal necrolysis Hypersensitivity reaction Epidermal necrosis Stevens-Johnson Syndrome bacteria business medicine.drug |
| Zdroj: | Indian Journal of Pharmacology |
| ISSN: | 1998-3751 0253-7613 |
| Popis: | Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a severe cutaneous drug reaction with a high mortality. Immune response is the possible cause in its pathogenesis. Levofloxacin is one of the most commonly used quinolones and has been reported to cause of TEN. On the other hand, furazolidone was proposed to augment the action of immediate hypersensitivity of levofloxacin by its cytotoxic effect and by the generation of free radicals. Here, we present a case of TEN where, levofloxacin and furazolidone were the probable cause of these adverse drug reactions. |
| Databáze: | OpenAIRE |
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