Paresordin A, a new diphenyl cyclic peroxide from the lichen Parmotrema praesorediosum
| Autor: | Tan Phat Nguyen, Nguyen Kim Tuyen Pham, Bui Linh Chi Huynh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Chemistry Depsidone Organic Chemistry Pharmaceutical Science General Medicine biology.organism_classification 01 natural sciences Peroxide 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Drug Discovery Parmeliaceae Parmotrema praesorediosum Molecular Medicine Protocetraric acid Lichen Nuclear chemistry |
| DOI: | 10.6084/m9.figshare.14363011.v1 |
| Popis: | From the lichen Parmotrema praesorediosum, one new diphenyl peroxide, named praesordin A (1), together with four depsidones, including virensic acid (2), protocetraric acid (3), 8'-O-methylprotocetraric acid (4), and furfuric acid (5) were purified. Their structures were chacracterized using extensive HR-ESI-MS and NMR spectroscopic methods. The isolated compounds (2-5) possessed stronger ��-glucosidase inhibitory activity (IC50 = 43.7-110.1 ��M) than the standard drug acarbose (IC50 = 214.5 ��M). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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