Radial Peripapillary Capillary Plexus Sparing and Underlying Retinal Vascular Impairment in Intermediate Age-Related Macular Degeneration
| Autor: | Lisa Nivison-Smith, Matt Trinh, Michael Kalloniatis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Capillary plexus genetic structures Fundus Oculi Visual Acuity Degeneration (medical) optical coherence tomography angiography Retina 03 medical and health sciences chemistry.chemical_compound Macular Degeneration 0302 clinical medicine Macula Lutea Ophthalmology Age related medicine Humans Fluorescein Angiography age-related macular degeneration Aged Retrospective Studies vessel perfusion business.industry Retinal Vessels Retinal Macular degeneration Middle Aged medicine.disease Tissue Degeneration 030104 developmental biology chemistry 030221 ophthalmology & optometry Female sense organs business Perfusion Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Investigative Ophthalmology & Visual Science |
| ISSN: | 1552-5783 |
| Popis: | Purpose To examine location-specific retinal vascular changes in intermediate age-related macular degeneration (iAMD) using age-matched, high-density en face optical coherence tomography angiography (OCTA) cluster analysis. Methods En face OCTA images of the 6 × 6 mm macular area were retrospectively acquired from 60 iAMD eyes and 60 age-matched normal eyes and then subdivided into 126 × 126 (47.62 × 47.62 µm) grids within the superficial and deep vascular complex. Grid-wise vessel perfusion (VP) were compared between iAMD and normal eyes from the corresponding 10-yearly age cohort, forming difference plots. Difference plots were further separated by normative topographical map spatial clusters (C1-6), derived from normaldatabase eyes (n = 236, 20–81 years old). Results Overall difference plots showed decreased VP in the superficial (−12.19%) and deep vascular complex (−6.44%) of iAMD compared to normal eyes (P < 0.0001 both comparisons). Cluster-based difference plots highlighted nonuniform changes in the superficial vascular complex, with sparing of VP at the nasal macula (corresponding to the radial peripapillary capillary plexus) versus decreased VP toward the temporal macula and foveal avascular zone (FAZ) (C1–6 all comparisons P < 0.0001, except C1 vs. C2 P > 0.99 and C4 vs. C5 P = 0.11). The deep vascular complex displayed diffusely decreased VP, greater at the FAZ (P < 0.0001). Conclusions High-density en face OCTA cluster analysis suggests relative sparing of the radial peripapillary capillary plexus and impairment of underlying retinal vasculature, supporting potential anterograde transsynaptic degeneration in iAMD. These location-specific data may better guide future diagnostic and management protocol of iAMD. |
| Databáze: | OpenAIRE |
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